Regulation of fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCTD20, FYTTD1, and TOPBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fatty acid biosynthetic process activity versus KCTD20 in CCRCC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KCTD20 →	-0.160	-0.117	.005	.002	3	4
BRCA	FYTTD1 →	-0.658	-0.216	<.001	.002	3	4
BRCA	TOPBP1 →	-0.498	-0.203	<.001	.003	3	4
BRCA	KPNA4 →	-0.338	-0.203	<.001	<.001	3	4
COAD	SERPING1 →	+1.043	+0.172	<.001	<.001	3	4
CCRCC	KCNE3 →	-0.561	-0.110	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042304 vs KCTD20 — CCRCC

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