Error-prone translesion synthesis

Across TCGA patient cohorts, RNA activity of the Error-prone translesion synthesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM4, LMNB1, and KIF11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Error-prone translesion synthesis activity versus MCM4 in LSCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM4 →	+0.765	+0.331	<.001	.004	3	6
BRCA	LMNB1 →	+0.826	+0.603	<.001	<.001	3	6
UCEC	KIF11 →	+0.864	+0.314	<.001	.002	3	6
GBM	BRIP1 →	+0.667	+0.341	<.001	.002	3	6
GBM	GART →	+0.189	+0.335	.001	.002	3	6
BRCA	DSCC1 →	+0.706	+0.471	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042276 vs MCM4 — LSCC

Explore this scatter interactively →