Ribosomal small subunit biogenesis

Across TCGA cell cohorts, RNA activity of the Ribosomal small subunit biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCFC2, SESN1, and C10orf95, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GCFC2 grouped by Ribosomal small subunit biogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GCFC2 →	-0.667	-0.306	<.001	.003	3	5
SOFT_TISSUE	SESN1 →	+1.282	+0.409	.005	.009	3	4
LUNG_NSCLC_LUSC	C10orf95 →	-0.497	-0.235	.002	.004	3	4
LUNG_NSCLC_LUSC	RFTN1 →	+3.158	+0.312	.007	.009	3	4
LUNG_NSCLC_LUSC	TRIM11 →	-0.512	-0.228	.009	.006	3	4
BLOOD_Leukemia	E2F3 →	-0.928	-0.276	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GCFC2 by Ribosomal small subunit biogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →