Ribosomal large subunit biogenesis

Across TCGA cell cohorts, RNA activity of the Ribosomal large subunit biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTBP2, TTC27, and AZIN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LTBP2 grouped by Ribosomal large subunit biogenesis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LTBP2 →	+2.013	+0.253	.006	.003	3	5
SOFT_TISSUE	TTC27 →	+0.645	+0.329	.005	.006	3	5
LUNG_NSCLC_LUSC	AZIN2 →	+1.773	+0.285	.004	.004	3	4
BLOOD_Lymphoma	BNIP3L →	+1.856	+0.510	<.001	<.001	2	5
SOFT_TISSUE	ZNF587B →	+1.093	+0.449	.001	.001	3	3
SKIN	MMP21 →	-0.048	-0.266	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LTBP2 by Ribosomal large subunit biogenesis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →