Protection from natural killer cell mediated cytotoxicity

Across TCGA patient cohorts, RNA activity of the Protection from natural killer cell mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP4, GBP2, and HLA-C, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protection from natural killer cell mediated cytotoxicity activity versus GBP4 in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBP4 →	+0.989	+0.172	.002	.004	3	7
BRCA	GBP2 →	+0.690	+0.250	.003	.005	3	7
BRCA	HLA-C →	+0.922	+0.297	<.001	<.001	3	6
BRCA	TAP2 →	+1.098	+0.234	<.001	<.001	3	6
BRCA	HLA-B →	+0.892	+0.203	<.001	<.001	3	6
BRCA	NLRC5 →	+0.809	+0.169	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042270 vs GBP4 — BRCA

Explore this scatter interactively →