Protection from natural killer cell mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the Protection from natural killer cell mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN4, PML, and SEC61A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN4 grouped by Protection from natural killer cell mediated cytotoxicity-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PTPN4 →	-0.601	-0.994	.002	.002	3	5
LUNG_NSCLC_LUSC	PML →	-0.994	-0.693	.008	.003	2	5
BLOOD_Lymphoma	SEC61A2 →	+1.269	+2.162	.008	<.001	3	4
SOFT_TISSUE	NNMT →	-4.661	-1.246	<.001	.001	3	4
CNS	MX2 →	-1.598	-0.720	<.001	.001	2	5
CNS	OSBPL5 →	-0.883	-0.701	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN4 by Protection from natural killer cell mediated cytotoxicity activity — LUNG_SCLC

Explore this box plot interactively →