Protection from natural killer cell mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the Protection from natural killer cell mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, B2M, and PSMB8, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protection from natural killer cell mediated cytotoxicity activity versus HLA-B in LUNG_SCLC (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HLA-B →	+6.411	+1.867	<.001	<.001	3	15
LUNG_SCLC	B2M →	+2.402	+1.836	<.001	<.001	3	13
LUNG_SCLC	PSMB8 →	+2.935	+1.357	<.001	.002	3	13
LUNG_SCLC	TAP1 →	+3.100	+1.486	<.001	<.001	3	12
LUNG_SCLC	HLA-C →	+4.638	+1.569	<.001	.001	3	12
LUNG_SCLC	PSMB9 →	+2.731	+1.116	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042270 vs HLA-B — LUNG_SCLC

Explore this scatter interactively →