Cytosolic ribosome assembly

Across TCGA patient cohorts, RNA activity of the Cytosolic ribosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF280D, MATR3, and MYSM1, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytosolic ribosome assembly activity versus ZNF280D in UVM (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ZNF280D →	+1.096	+0.060	<.001	<.001	3	32
UVM	MATR3 →	+0.980	+0.070	<.001	<.001	3	32
UVM	MYSM1 →	+1.865	+0.070	<.001	<.001	3	32
KICH	NFXL1 →	+1.324	+0.053	<.001	<.001	3	32
UVM	THOC2 →	+1.603	+0.062	<.001	<.001	3	32
UVM	DMXL2 →	+1.195	+0.055	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042256 vs ZNF280D — UVM

Explore this scatter interactively →