Ribosome assembly

Across TCGA cell cohorts, RNA activity of the Ribosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR12, DHX37, and NCL, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosome assembly activity versus WDR12 in BLOOD_Lymphoma (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	WDR12 →	+1.143	+0.085	<.001	<.001	3	20
SKIN	DHX37 →	+1.241	+0.084	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	NCL →	+0.925	+0.068	<.001	<.001	3	18
BONE	CLUH →	+1.591	+0.135	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	MRM3 →	+0.929	+0.082	.005	<.001	3	18
BLOOD_Myeloma	DDX28 →	+1.348	+0.123	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042255 vs WDR12 — BLOOD_Lymphoma

Explore this scatter interactively →