Cellular modified amino acid catabolic process

Across TCGA cell cohorts, RNA activity of the Cellular modified amino acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL49, ZBTB10, and MTFR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPL49 grouped by Cellular modified amino acid catabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MRPL49 →	+0.567	+0.938	.002	.009	3	4
CNS	ZBTB10 →	+0.624	+0.903	.006	.002	3	4
URINARY_TRACT	MTFR2 →	+0.990	+1.800	.005	<.001	3	4
URINARY_TRACT	ZFPM1 →	-1.181	-1.298	.003	.004	3	3
BLOOD_Leukemia	RADIL →	+1.379	+1.541	.004	<.001	2	4
BLOOD_Lymphoma	NARS1 →	+0.870	+1.630	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPL49 by Cellular modified amino acid catabolic process activity — STOMACH

Explore this box plot interactively →