Ketone catabolic process

Across TCGA patient cohorts, RNA activity of the Ketone catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AHNAK_S3294, AHNAK_S1452, and CLDN23_S203, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ketone catabolic process activity versus AHNAK_S3294 in LUAD (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AHNAK_S3294 →	+0.360	+0.059	.001	<.001	3	6
PDAC	AHNAK_S1452 →	+0.828	+0.052	.001	.005	3	5
GBM	CLDN23_S203 →	+0.811	+0.088	<.001	<.001	3	5
GBM	IQSEC2_S412 →	+0.518	+0.058	<.001	<.001	3	5
GBM	PDS5B →	-0.272	-0.070	<.001	<.001	3	5
COAD	SFXN3 →	+0.290	+0.057	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042182 vs AHNAK_S3294 — LUAD

Explore this scatter interactively →