Ketone catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Ketone catabolic process pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in lung adenocarcinoma (LUAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRC and CHOL, show the opposite pattern, with lower activity in tumor tissue.

LUAD, LUSC, and KIRC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LUAD	Male	All	+0.050	<.001	10	view →
LUSC	Female	All	+0.060	<.001	8	view →
KIRC	Male	All	−0.049	<.001	8	view →
BRCA	Female	All	+0.037	<.001	6	view →
CHOL	Male	All	−0.168	<.001	5	view →
KICH	All	All	−0.041	.007	3	view →
COAD	All	IV	+0.057	.001	2	view →
KIRP	All	All	−0.034	.027	2	view →
LIHC	All	II,III,IV	−0.027	.031	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:0042182–LUAD

Open the LUAD breakdown →