Ketone catabolic process

Across TCGA patient cohorts, RNA activity of the Ketone catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNKD, GPC6, and LILRB4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ketone catabolic process activity versus PNKD in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PNKD →	+0.607	+0.128	<.001	.001	2	7
LUAD	GPC6 →	-0.841	-0.187	<.001	<.001	3	5
OV	LILRB4 →	+0.872	+0.195	.005	.002	3	5
GBM	NANOS3 →	-0.521	-0.138	<.001	<.001	3	5
UCEC	RN7SL634P →	+0.640	+0.180	.005	.001	3	4
LUAD	CEBPA →	+0.709	+0.155	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042182 vs PNKD — BRCA

Explore this scatter interactively →