Ketone catabolic process

Across TCGA cell cohorts, RNA activity of the Ketone catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC16A9, HAGH, and YBEY, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ketone catabolic process activity versus SLC16A9 in BLOOD_Leukemia (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC16A9 →	+1.739	+0.939	.004	.007	3	6
BLOOD_Lymphoma	HAGH →	+1.583	+1.197	<.001	<.001	3	6
OESOPHAGUS	YBEY →	+1.119	+0.894	.002	.004	3	6
BLOOD_Leukemia	TMEM64 →	+1.970	+1.328	<.001	<.001	3	5
BLOOD_Lymphoma	MAN2A2 →	+1.366	+0.971	.001	<.001	2	6
BLOOD_Lymphoma	BLVRA →	+3.312	+1.049	.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042182 vs SLC16A9 — BLOOD_Leukemia

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