Ketone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ketone biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BGN, SFRP1, and GSTM5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ketone biosynthetic process activity versus BGN in CCRCC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BGN →	+0.974	+0.041	<.001	.001	3	5
LUAD	SFRP1 →	+0.373	+0.027	<.001	<.001	3	5
UCEC	GSTM5 →	+0.642	+0.039	.004	.002	3	5
CCRCC	PLCXD3 →	+0.557	+0.031	<.001	<.001	3	5
CCRCC	ARHGEF17 →	+0.282	+0.036	<.001	<.001	3	5
CCRCC	POLR2H →	-0.277	-0.030	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042181 vs BGN — CCRCC

Explore this scatter interactively →