Xenobiotic catabolic process

Across TCGA patient cohorts, RNA activity of the Xenobiotic catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTM1, GSTM4, and GSTM2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic catabolic process activity versus GSTM1 in HNSC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GSTM1 →	+2.137	+0.269	<.001	<.001	3	8
LSCC	GSTM4 →	+0.746	+0.188	<.001	<.001	3	5
BRCA	GSTM2 →	+0.673	+0.134	<.001	<.001	3	5
BRCA	EMX1 →	+0.622	+0.118	<.001	.004	3	4
CCRCC	UQCRC2 →	+0.340	+0.198	.004	.008	3	4
LSCC	GSR →	+0.750	+0.180	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042178 vs GSTM1 — HNSC

Explore this scatter interactively →