Cellular response to glucose starvation

Across TCGA cell cohorts, RNA activity of the Cellular response to glucose starvation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSSC4, NECTIN4, and SPPL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to glucose starvation activity versus TSSC4 in BREAST (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TSSC4 →	-0.513	-0.154	.002	.002	3	5
BREAST	NECTIN4 →	-2.119	-0.206	.003	<.001	3	4
STOMACH	SPPL3 →	-0.947	-0.284	.004	.001	3	4
BLOOD_Myeloma	SFSWAP →	-0.882	-0.164	<.001	.001	3	4
BLOOD_Lymphoma	SRCAP →	-1.028	-0.111	.008	.007	3	4
BLOOD_Myeloma	MOB2 →	-0.507	-0.144	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042149 vs TSSC4 — BREAST

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