DNA strand invasion

Across TCGA cell cohorts, RNA activity of the DNA strand invasion pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LENEP, IKZF4, and SEPTIN8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LENEP grouped by DNA strand invasion-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	LENEP →	+0.484	+0.191	<.001	.003	3	4
BLOOD_Leukemia	IKZF4 →	+0.983	+0.288	.002	.005	3	4
BREAST	SEPTIN8 →	+0.989	+0.137	<.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	CCZ1B →	+0.741	+0.198	.009	.005	2	5
LIVER	LPAR6 →	-2.004	-0.240	.003	.008	3	4
LIVER	ASB4 →	-1.081	-0.321	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LENEP by DNA strand invasion activity — OESOPHAGUS

Explore this box plot interactively →