Meiotic DNA double-strand break formation

Across TCGA patient cohorts, RNA activity of the Meiotic DNA double-strand break formation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRE11, PLD2, and NSD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic DNA double-strand break formation activity versus MRE11 in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRE11 →	+0.325	+0.459	.001	<.001	3	4
LUAD	PLD2 →	-0.244	-0.432	.003	.005	3	3
UCEC	NSD3 →	+0.347	+0.644	.008	.001	3	3
UCEC	BTF3P12 →	+0.659	+0.535	.005	.002	3	3
BRCA	PARN →	+0.352	+0.432	<.001	.004	3	3
OV	MANSC1 →	-0.791	-0.351	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042138 vs MRE11 — UCEC

Explore this scatter interactively →