Meiotic DNA double-strand break formation

Across TCGA cell cohorts, RNA activity of the Meiotic DNA double-strand break formation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C9orf40, CYP20A1, and CWC22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C9orf40 grouped by Meiotic DNA double-strand break formation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	C9orf40 →	+1.295	+1.819	.001	<.001	3	4
BLOOD_Myeloma	CYP20A1 →	+1.118	+1.336	.007	.003	3	4
SOFT_TISSUE	CWC22 →	+0.702	+0.970	.002	.006	3	3
LUNG_NSCLC_LUSC	SND1 →	-0.613	-1.313	.008	<.001	3	3
LUNG_NSCLC_LUAD	RAP1GDS1 →	+0.638	+1.079	.001	<.001	3	3
LUNG_NSCLC_LUAD	PYURF →	+0.517	+1.091	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C9orf40 by Meiotic DNA double-strand break formation activity — KIDNEY

Explore this box plot interactively →