Meiotic DNA double-strand break formation

Across TCGA cell cohorts, RNA activity of the Meiotic DNA double-strand break formation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRE11, BUD13, and ANKRD49, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic DNA double-strand break formation activity versus MRE11 in LARGE_INTESTINE (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MRE11 →	+1.265	+1.119	<.001	<.001	3	13
KIDNEY	BUD13 →	+0.759	+1.289	.001	.002	3	11
LARGE_INTESTINE	ANKRD49 →	+0.795	+0.569	<.001	.002	3	10
CNS	TAF1D →	+0.782	+1.084	<.001	<.001	3	10
STOMACH	VPS9D1 →	-0.809	-0.197	.006	.006	3	10
CNS	CWF19L2 →	+0.690	+1.037	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042138 vs MRE11 — LARGE_INTESTINE

Explore this scatter interactively →