Monocyte activation

Across TCGA patient cohorts, RNA activity of the Monocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEFV, PELATON, and CSF3R, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocyte activation activity versus MEFV in LUAD (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MEFV →	+0.588	+0.187	<.001	.003	3	5
UCEC	PELATON →	+0.484	+0.173	.001	.005	3	5
GBM	CSF3R →	+0.892	+0.237	.001	<.001	2	6
GBM	LAPTM5 →	+1.060	+0.236	<.001	<.001	3	5
GBM	LILRB4 →	+0.795	+0.175	<.001	.003	3	5
CCRCC	AQP9 →	+1.158	+0.222	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042117 vs MEFV — LUAD

Explore this scatter interactively →