Macrophage activation

Across TCGA cell cohorts, RNA activity of the Macrophage activation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTP4, CASP1, and IRF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage activation activity versus RTP4 in LARGE_INTESTINE (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RTP4 →	-1.378	-0.746	.001	.002	3	8
LIVER	CASP1 →	-3.170	-1.073	<.001	.003	3	7
BREAST	IRF1 →	-2.130	-0.735	<.001	.001	3	7
LARGE_INTESTINE	HLA-B →	-2.599	-0.585	.002	.007	3	7
BREAST	GBP1 →	-3.030	-0.439	<.001	.008	3	6
BONE	APOL3 →	-2.142	-1.321	.004	.008	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042116 vs RTP4 — LARGE_INTESTINE

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