Positive regulation of activated T cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of activated T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXW8, MAPK8IP2, and BCL9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXW8 grouped by Positive regulation of activated T cell proliferation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FBXW8 →	-0.598	-1.292	.001	<.001	3	5
SOFT_TISSUE	MAPK8IP2 →	-1.418	-1.085	.005	<.001	3	5
LUNG_SCLC	BCL9 →	-1.008	-1.385	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	STK26 →	+0.956	+0.854	.006	.005	3	3
LUNG_NSCLC_LUSC	MBOAT1 →	+1.345	+1.189	.007	.008	3	3
LARGE_INTESTINE	SHQ1 →	+0.649	+0.861	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXW8 by Positive regulation of activated T cell proliferation activity — OVARY

Explore this box plot interactively →