Positive regulation of activated T cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of activated T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL18, CARD11, and HBEGF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of activated T cell proliferation activity versus METTL18 in OVARY (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	METTL18 →	-0.912	-0.308	<.001	.006	3	5
LUNG_NSCLC_LUAD	CARD11 →	-2.380	-0.312	<.001	.008	3	4
OESOPHAGUS	HBEGF →	-1.703	-0.201	.003	.001	3	4
OESOPHAGUS	PERM1 →	-0.708	-0.182	.004	.006	3	3
LUNG_SCLC	ONECUT2 →	+1.255	+0.177	.007	.006	3	3
LUNG_SCLC	NUDT7 →	+1.776	+0.259	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042104 vs METTL18 — OVARY

Explore this scatter interactively →