T cell proliferation

Across TCGA cell cohorts, RNA activity of the T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOBTB3, SPATA2L, and SLC25A13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHOBTB3 grouped by T cell proliferation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RHOBTB3 →	-3.453	-1.268	.003	.001	3	4
CNS	SPATA2L →	+0.478	+0.703	.004	.005	3	4
BLOOD_Leukemia	SLC25A13 →	-1.048	-0.813	.001	.005	3	4
BREAST	TMEM63B →	+0.909	+0.844	.005	.005	3	4
PANCREAS	CCDC189 →	+0.715	+0.941	.004	.008	3	4
OESOPHAGUS	NPIPB11 →	+0.452	+1.295	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHOBTB3 by T cell proliferation activity — STOMACH

Explore this box plot interactively →