T-helper 1 type immune response

Across TCGA cell cohorts, RNA activity of the T-helper 1 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EHD1, TMPRSS6, and STRIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EHD1 grouped by T-helper 1 type immune response-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EHD1 →	+1.221	+0.435	.002	.004	3	4
KIDNEY	TMPRSS6 →	+0.096	+0.209	.001	.002	3	4
LUNG_NSCLC_LUAD	STRIP1 →	-0.383	-0.126	.008	.004	3	4
BREAST	TMED7 →	+0.685	+0.113	.007	.004	3	4
LUNG_SCLC	MOCS2 →	+0.906	+0.207	<.001	.002	3	4
BLOOD_Leukemia	UCK2 →	-0.620	-0.204	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EHD1 by T-helper 1 type immune response activity — LIVER

Explore this box plot interactively →