Regulation of catecholamine metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of catecholamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARRDC5, CD33, and ARHGAP9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of catecholamine metabolic process activity versus ARRDC5 in GBM (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARRDC5 →	+0.714	+0.157	<.001	.001	3	6
GBM	CD33 →	+0.565	+0.126	<.001	<.001	3	6
BRCA	ARHGAP9 →	+0.622	+0.124	.003	.002	3	6
GBM	BCL2A1 →	+1.121	+0.131	<.001	<.001	3	6
GBM	ITGAX →	+0.645	+0.134	<.001	<.001	3	6
GBM	DOK3 →	+0.560	+0.121	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042069 vs ARRDC5 — GBM

Explore this scatter interactively →