Regulation of catecholamine metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of catecholamine metabolic process pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 20 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Regulation of catecholamine metabolic process pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

HNSC, SKCM, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.706	0.537	<.001	88	view →
SKCM	OS	Median	All	0.412	0.282	<.001	72	view →
UVM	DFS	Tertile	All	0.875	0.469	<.001	71	view →
BRCA	DFS	Tertile	III,IV	0.931	0.816	.002	58	view →
ACC	DFS	Median	All	0.805	0.516	.002	42	view →
COAD	OS	Tertile	III,IV	0.937	0.678	.003	39	view →
LGG	DFS	Tertile	All	0.299	0.428	<.001	37	view →
KIRP	OS	Median	III,IV	0.739	0.167	<.001	30	view →
GBM	DFS	Quartile	All	0.174	0.561	<.001	27	view →
THYM	DFS	Median	All	0.741	0.971	.004	23	view →
SARC	OS	Median	All	0.894	0.781	<.001	23	view →
LUAD	OS	Quartile	All	0.582	0.302	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0042069–HNSC (DFS)

Open the HNSC breakdown →