Regulation of catecholamine metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of catecholamine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACAP1_T739, ITGAM, and ITGB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of catecholamine metabolic process activity versus ACAP1_T739 in GBM (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ACAP1_T739 →	+1.070	+0.191	<.001	<.001	3	6
GBM	ITGAM →	+0.743	+0.171	<.001	<.001	3	6
GBM	ITGB2 →	+0.593	+0.132	<.001	<.001	3	6
COAD	ABAT →	+0.763	+0.128	<.001	<.001	3	5
LSCC	INPP5D_S243 →	+0.663	+0.140	<.001	<.001	3	5
OV	FMNL1_S184 →	+0.904	+0.197	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042069 vs ACAP1_T739 — GBM

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