Regulation of catecholamine metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of catecholamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTH1, SLC2A11, and KLHL8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYTH1 grouped by Regulation of catecholamine metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CYTH1 →	+0.688	+0.485	.004	.007	3	3
LARGE_INTESTINE	SLC2A11 →	+1.303	+1.217	<.001	.001	3	3
LARGE_INTESTINE	KLHL8 →	+0.587	+0.735	.003	<.001	3	3
LARGE_INTESTINE	ZBTB8A →	+0.633	+0.665	.001	.002	3	3
OVARY	KIAA0895 →	+0.981	+0.554	<.001	.003	3	3
LARGE_INTESTINE	MTMR10 →	+0.582	+0.859	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYTH1 by Regulation of catecholamine metabolic process activity — BREAST

Explore this box plot interactively →