Regulation of catecholamine metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of catecholamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRXL2B, NOB1, and ACBD5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of catecholamine metabolic process activity versus PRXL2B in STOMACH (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRXL2B →	+1.540	+0.423	.001	.005	3	7
LARGE_INTESTINE	NOB1 →	+0.806	+0.281	.006	.001	3	6
LARGE_INTESTINE	ACBD5 →	+1.071	+0.288	<.001	.001	3	5
STOMACH	EEF2 →	+1.410	+0.463	<.001	<.001	3	5
BONE	DDX28 →	+0.699	+0.306	.001	.003	3	5
PANCREAS	METTL21A →	+0.904	+0.368	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042069 vs PRXL2B — STOMACH

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