Olfactory behavior

Across TCGA cell cohorts, RNA activity of the Olfactory behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAGEC2, ACOT8, and ADAM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAGEC2 grouped by Olfactory behavior-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MAGEC2 →	-0.132	-0.128	.003	.009	2	5
LARGE_INTESTINE	ACOT8 →	-0.357	-0.326	<.001	<.001	3	4
LARGE_INTESTINE	ADAM2 →	+0.321	+0.303	<.001	<.001	3	4
BLOOD_Myeloma	SREBF2 →	-0.202	-0.321	.001	<.001	3	3
BLOOD_Leukemia	KLF5 →	-0.247	-1.025	.002	.004	3	3
BLOOD_Leukemia	PIK3C2A →	-0.338	-0.713	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAGEC2 by Olfactory behavior activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →