Epithelial fluid transport

Across TCGA patient cohorts, RNA activity of the Epithelial fluid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIF1_S782, CDCA8_S219, and NCL_S67, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial fluid transport activity versus RIF1_S782 in LSCC (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RIF1_S782 →	-0.772	-0.104	<.001	<.001	3	8
COAD	CDCA8_S219 →	-0.544	-0.067	.001	.003	3	8
UCEC	NCL_S67 →	-0.714	-0.103	<.001	<.001	3	8
UCEC	TOP2A_S1247 →	-1.000	-0.070	<.001	<.001	3	8
LSCC	HEATR1 →	-0.339	-0.096	<.001	<.001	3	8
LSCC	SLC4A1AP →	-0.339	-0.116	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042045 vs RIF1_S782 — LSCC

Explore this scatter interactively →