Epithelial fluid transport

Across TCGA cell cohorts, RNA activity of the Epithelial fluid transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATS2L, ZBTB18, and ZNF416, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPATS2L grouped by Epithelial fluid transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SPATS2L →	+0.730	+0.987	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ZBTB18 →	+0.933	+0.761	.002	.002	3	4
BLOOD_Leukemia	ZNF416 →	+0.660	+0.889	.001	.003	3	4
LUNG_NSCLC_LUSC	UPP1 →	-1.859	-1.360	<.001	.004	3	4
SOFT_TISSUE	THSD1 →	+1.745	+1.074	.002	.002	3	4
CNS	SAXO2 →	+0.791	+1.036	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPATS2L by Epithelial fluid transport activity — CNS

Explore this box plot interactively →