Fluid transport

Across TCGA cell cohorts, RNA activity of the Fluid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR176, LMBR1L, and NIT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR176 grouped by Fluid transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR176 →	-1.421	-0.841	<.001	.001	3	4
LUNG_NSCLC_LUSC	LMBR1L →	+0.851	+1.382	.007	<.001	3	4
LUNG_NSCLC_LUAD	NIT1 →	+0.447	+0.666	.006	.002	3	4
LUNG_NSCLC_LUAD	ESPN →	+1.586	+0.829	.007	.006	3	4
SOFT_TISSUE	TMEM168 →	-0.775	-1.094	.005	.002	3	4
LARGE_INTESTINE	PMF1 →	+0.487	+0.907	.006	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR176 by Fluid transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →