Fluid transport

Across TCGA pan-cancer cohorts, RNA activity of the Fluid transport pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 37 member genes.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher Fluid transport pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and UCEC, show the opposite pattern, with higher activity associated with better survival.

DLBC, ESCA, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	II,III,IV	0.107	0.951	<.001	67	view →
ESCA	DFS	Tertile	II,III,IV	0.657	0.378	.001	65	view →
UCEC	DFS	Median	All	0.935	0.861	.002	48	view →
LGG	DFS	Median	All	0.658	0.798	<.001	45	view →
KIRP	DFS	Tertile	II,III,IV	0.854	0.489	.006	34	view →
READ	DFS	Tertile	III,IV	0.293	0.785	.002	34	view →
MESO	OS	Tertile	II,III,IV	0.281	0.786	.002	33	view →
SCLC	DFS	Median	All	0.146	0.396	.004	30	view →
THCA	OS	Quartile	II,III,IV	0.938	0.997	.001	28	view →
LAML	DFS	Quartile	All	0.728	0.282	.002	24	view →
COAD	OS	Tertile	IV	0.656	0.288	.003	22	view →
OV	DFS	Quartile	All	0.453	0.589	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0042044–DLBC (DFS)

Open the DLBC breakdown →