Fluid transport

Across TCGA cell cohorts, RNA activity of the Fluid transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPM1, COPS9, and SLC35E1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fluid transport activity versus DPM1 in OESOPHAGUS (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DPM1 →	-1.105	-1.699	<.001	<.001	3	4
LUNG_NSCLC_LUSC	COPS9 →	-0.589	-1.394	.007	.008	2	5
LUNG_NSCLC_LUAD	SLC35E1 →	-0.544	-1.505	.003	<.001	3	3
LUNG_NSCLC_LUAD	HK2 →	-2.254	-1.582	.001	.002	3	3
LUNG_NSCLC_LUAD	ZNF654 →	-0.742	-1.808	.005	<.001	3	3
LUNG_NSCLC_LUAD	ZNF501 →	-1.202	-1.539	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042044 vs DPM1 — OESOPHAGUS

Explore this scatter interactively →