Regulation of fibroblast growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of fibroblast growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP1, COL1A1, and COL5A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fibroblast growth factor receptor signaling pathway activity versus LRP1 in LSCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LRP1 →	+0.677	+0.228	.001	<.001	3	7
OV	COL1A1 →	+2.289	+0.678	<.001	.002	3	7
LSCC	COL5A1 →	+1.393	+0.386	<.001	<.001	3	7
HNSC	HMCN1 →	+0.662	+0.122	.009	.004	3	6
LUAD	MRC2 →	+0.662	+0.478	<.001	<.001	3	6
BRCA	FBN1 →	+0.723	+0.307	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040036 vs LRP1 — LSCC

Explore this scatter interactively →