snRNA modification

Across TCGA patient cohorts, RNA activity of the snRNA modification pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, HIC1, and ASPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA modification activity versus CNRIP1 in OV (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CNRIP1 →	-0.920	-0.197	<.001	.002	3	6
OV	HIC1 →	-0.583	-0.180	.005	.003	3	6
COAD	ASPA →	-0.327	-0.180	.006	<.001	3	6
LSCC	STARD8 →	-0.422	-0.208	<.001	<.001	3	6
PDAC	MITF →	-0.490	-0.111	<.001	.002	3	6
OV	PMP22 →	-0.852	-0.220	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040031 vs CNRIP1 — OV

Explore this scatter interactively →