Regulation of meiotic nuclear division

Across TCGA cell cohorts, RNA activity of the Regulation of meiotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RMND5A, BLOC1S6, and DDR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of meiotic nuclear division activity versus RMND5A in SKIN (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RMND5A →	-0.788	-0.391	.001	.002	3	4
STOMACH	BLOC1S6 →	+0.883	+0.493	.001	<.001	3	4
OESOPHAGUS	DDR1 →	-1.495	-0.325	.003	.009	3	3
OESOPHAGUS	RILPL2 →	-0.763	-0.333	.001	.004	3	3
OESOPHAGUS	IRF2BP2 →	-0.881	-0.360	.004	.002	3	3
STOMACH	BNIP3L →	+1.412	+0.384	.006	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040020 vs RMND5A — SKIN

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