Positive regulation of embryonic development

Across TCGA cell cohorts, RNA activity of the Positive regulation of embryonic development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UAP1L1, RUSF1, and TRIB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UAP1L1 grouped by Positive regulation of embryonic development-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	UAP1L1 →	-1.863	-0.282	.004	.002	2	5
STOMACH	RUSF1 →	-0.644	-0.250	.006	.003	3	4
OESOPHAGUS	TRIB2 →	-1.643	-0.185	.001	.008	3	4
LUNG_SCLC	PROB1 →	-0.786	-0.191	.004	.003	3	4
PANCREAS	ARHGAP44 →	-0.731	-0.231	.006	.003	2	5
PANCREAS	ZNF416 →	-0.712	-0.350	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UAP1L1 by Positive regulation of embryonic development activity — URINARY_TRACT

Explore this box plot interactively →