Positive regulation of multicellular organism growth

Across TCGA patient cohorts, RNA activity of the Positive regulation of multicellular organism growth pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL6, RSL1D1, and SOX4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of multicellular organism growth activity versus RPL6 in GBM (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL6 →	-0.496	-0.055	.006	.001	3	5
BRCA	RSL1D1 →	-0.399	-0.032	.002	<.001	3	5
PDAC	SOX4 →	+0.448	+0.030	.002	.007	3	5
HNSC	GSTA4 →	+0.840	+0.038	.001	.008	3	5
CCRCC	AMPD3 →	-0.350	-0.054	<.001	<.001	3	5
GBM	RPL7L1 →	-0.308	-0.044	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040018 vs RPL6 — GBM

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