Positive regulation of multicellular organism growth

Across TCGA cell cohorts, RNA activity of the Positive regulation of multicellular organism growth pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EZR, SIN3B, and CRMP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of multicellular organism growth activity versus EZR in OESOPHAGUS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EZR →	+1.938	+0.223	.004	.003	3	9
PANCREAS	SIN3B →	-0.787	-0.229	.004	<.001	3	6
STOMACH	CRMP1 →	-2.201	-0.386	.002	.004	3	6
STOMACH	SMARCAL1 →	-0.497	-0.323	.003	.008	2	6
BLOOD_Leukemia	MAST1 →	-1.437	-0.191	.002	.004	2	6
LARGE_INTESTINE	CHN1 →	-2.024	-0.311	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040018 vs EZR — OESOPHAGUS

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