Embryonic cleavage

Across TCGA patient cohorts, RNA activity of the Embryonic cleavage pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PNKP, ADNP, and SAE1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic cleavage activity versus PNKP in HNSC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PNKP →	+0.275	+0.061	.001	.005	3	7
HNSC	ADNP →	+0.370	+0.086	<.001	<.001	3	6
GBM	SAE1 →	+0.249	+0.037	.001	.002	3	6
HNSC	ZFR →	+0.244	+0.087	.001	<.001	3	6
GBM	TRIM28 →	+0.292	+0.047	<.001	<.001	3	6
LSCC	RUVBL1 →	+0.301	+0.056	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040016 vs PNKP — HNSC

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