Embryonic cleavage

Across TCGA patient cohorts, RNA activity of the Embryonic cleavage pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIRC5, ASPA, and ABCA8, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic cleavage activity versus BIRC5 in UCEC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BIRC5 →	+1.687	+0.488	<.001	<.001	3	10
GBM	ASPA →	-0.769	-0.204	<.001	<.001	3	9
UCEC	ABCA8 →	-1.196	-0.305	<.001	<.001	3	9
LUAD	PRR11 →	+1.052	+0.348	<.001	<.001	3	9
UCEC	BORA →	+0.827	+0.441	<.001	<.001	3	8
LUAD	RACGAP1 →	+0.999	+0.356	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040016 vs BIRC5 — UCEC

Explore this scatter interactively →