Embryonic cleavage

Across TCGA patient cohorts, RNA activity of the Embryonic cleavage pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1247, TOP2A_S1525, and RFC1_T506, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic cleavage activity versus TOP2A_S1247 in LUAD (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A_S1247 →	+1.598	+0.376	<.001	<.001	3	10
LSCC	TOP2A_S1525 →	+1.206	+0.401	<.001	<.001	3	9
LUAD	RFC1_T506 →	+1.146	+0.366	<.001	<.001	3	8
LUAD	RPL12_S38 →	+1.296	+0.334	<.001	<.001	3	8
LUAD	TOP2A_S1106 →	+1.335	+0.360	<.001	<.001	3	8
LUAD	KIF11_T926 →	+1.037	+0.289	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040016 vs TOP2A_S1247 — LUAD

Explore this scatter interactively →