Negative regulation of multicellular organism growth

Across TCGA patient cohorts, RNA activity of the Negative regulation of multicellular organism growth pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYGB, SYTL4_S296, and ALDH1A1_S413, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of multicellular organism growth activity versus CYGB in PDAC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CYGB →	+0.450	+0.065	<.001	<.001	3	5
HNSC	SYTL4_S296 →	+0.416	+0.046	<.001	.006	3	5
HNSC	ALDH1A1_S413 →	+0.855	+0.069	<.001	<.001	3	5
PDAC	CD34 →	+0.352	+0.048	.003	<.001	3	5
BRCA	SYTL4_S74 →	+0.891	+0.039	<.001	<.001	3	4
BRCA	EEF1D →	-0.226	-0.034	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040015 vs CYGB — PDAC

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