Negative regulation of multicellular organism growth

Across TCGA cell cohorts, RNA activity of the Negative regulation of multicellular organism growth pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL22, SLC4A3, and IL7R, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL22 grouped by Negative regulation of multicellular organism growth-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RPL22 →	-0.383	-0.223	<.001	<.001	3	6
BREAST	SLC4A3 →	-0.182	-0.132	.002	<.001	3	5
SOFT_TISSUE	IL7R →	-0.173	-0.251	.001	<.001	3	5
SKIN	KCNH8 →	-0.183	-0.153	<.001	<.001	3	5
SOFT_TISSUE	HDGFL1 →	-0.477	-0.301	<.001	<.001	3	5
CNS	MAEA →	-0.196	-0.124	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL22 by Negative regulation of multicellular organism growth activity — SKIN

Explore this box plot interactively →