Establishment of mitotic spindle localization

Across TCGA patient cohorts, RNA activity of the Establishment of mitotic spindle localization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP8, CD69, and DUSP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of mitotic spindle localization activity versus GIMAP8 in HNSC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GIMAP8 →	-0.688	-0.249	.001	.004	3	5
LUAD	CD69 →	-0.474	-0.171	.003	.001	3	5
LUAD	DUSP1 →	-0.549	-0.214	.005	.002	3	4
LUAD	KLF2 →	-0.418	-0.182	.007	<.001	3	4
LUAD	GMFG →	-0.277	-0.147	.007	.005	3	4
CCRCC	ETS1 →	-0.376	-0.556	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0040001 vs GIMAP8 — HNSC

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